Warning: Illegal string offset 'otw_pm_portfolio_detail_1' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Illegal string offset 'otw_pm_portfolio_detail_2' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Illegal string offset 'otw_pm_portfolio_detail_3' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Illegal string offset 'otw_pm_portfolio_detail_4' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Illegal string offset 'otw_pm_portfolio_detail_5' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Illegal string offset 'otw_pm_portfolio_detail_6' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 145

Warning: Illegal string offset 'media_type' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 155

Warning: Cannot assign an empty string to a string offset in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/classes/otw_pm_dispatcher.php on line 155
A phase I, multicenter open-label study of oral LGH447 in patients with acute myeloid leukemia or high risk myelodysplastic syndrome – Rete Ematologica Lombarda

Warning: Illegal string offset 'media_type' in /home/forge/www.rel-lombardia.net/wp-content/plugins/portfolio-manager-lite/skeleton/components/item_media.php on line 2

Project Description

Patologia AML/MDS
Sponsor Novartis Farma S.p.A
Farmaco LGH447
Fase 1
Linea pazienti con AML refrattaria o in recidiva o di nuova diagnosi o con MDS ad altro rischio
 
Codice studio CLGH447X2102
Obiettivo primario Obiettivo del seguente studio è valutare la massima dose tollerata (MTD) e/o la dose raccomandata per l’espansione (RDE) di LGH447 in pazienti con leucemia mieloide acuta (AML) o sindrome mielodisplastica ad alto rischio (MDS). Il razionale della valutazione del farmaco si basa sull’evidenza preclinica che LGH447, somministrato in monoterapia, dimostra inibizione della crescita cellulare in modelli di linee cellulari di AML che esprimono PIM1. La popolazione è rappresentata da pazienti di età > 18 con AML refrattaria/in recidiva o MDS a rischio alto o molto alto.
 
Responsabile della sperimentazione Prof. Fabio Ciceri, Ospedale San Raffaele Milano
Medici referenti Dr. Matteo Carrabba - Ospedale San Raffaele Milano
 
Data inizio dello studio 9 ottobre 2017
Durata dello studio Data fine arruolamento prevista: dicembre 2017
Stato del protocollo APERTO
 
Persona da contattare per l’invio di pazienti
e modalità di contatto
Prof. Fabio Ciceri, ciceri.clinicaltrials@hsr.it telefono: 0226434289
SCARICA LA SINOSSI DELLO STUDIO

Project Details